Caffeine poisoning can happen with 1,200 milligrams of pure caffeine, according to the FDA. That is less than half a teaspoon of caffeine in powder form. Other, more-common issues people have reported after drinking caffeinated drinks are trouble sleeping, loose stools and upset stomach. Overall, water is probably your best bet to stay hydrated. Caffeine is a naturally occurring central nervous system (CNS) stimulant of the methylxanthine class and is the most widely taken psychoactive stimulant globally. This drug is most commonly sourced from the coffee bean but can also be found naturally occurring in certain types of tea and cacao beans, and it is also an additive to soda and energy drinks. The primary goal of caffeine consumption Experts say that consuming more than 1,200 milligrams (mg) of caffeine—which would equal roughly 12 cups of coffee—within a short time can lead to dangerous side effects like seizures. Specific to epilepsy, some research has suggested that more than four cups of coffee per day might trigger more seizures than usual. [Chorus: Casey Lee Williams with Jeff Williams] Caffeine, I'm caffeine Caffeine, I'm caffeine I'm a bad dream I'm a rad scene I'm a tad mean But I'm not afraid to take you out (Afraid to take you We’ve already covered reasons why caffeine makes you feel tired, but if caffeine is having no effect on you at all, here are the main culprits: 1. You’ve Got a Lot of Sleep Debt. The RISE app can work out how much sleep debt you have. Sleep debt is how much sleep you owe your body over the last 14 nights. An increase in intracellular calcium has the potential to induce atrial arrhythmia by enhancing automaticity of atrial pacemaker cells and after depolarization-induced triggered activity (8). A dose of 250 mg of caffeine (3 cups of coffee) acutely increases norepinephrine and epinephrine by 75% and 207%, respectively (9). .

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